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Updated: Jul 28, 2026
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid
M J Nowicki1, L Benning, J W Bremer
1University of Southern California, Pediatrics, Los Angeles, California 90033, USA. marek@usc.edu
Abstract:
Human immunodeficiency virus type 1 (HIV-1) RNA measurements were evaluated within an externally controlled multilaboratory program. Three external standards (1.5 x 10(3) to 1.5 x 10(6) copies/ml) were included in 814 assay runs by four laboratories. Results indicate that HIV-1 RNA levels can be measured with a precision equal to that of the pre-highly active antiretroviral therapy era (standard deviations, +/-0.16 to 0.25 log10 units).
