[Levels of soluble thrombomodulin in blood of patients with lung cancer]

Thrombomodulin /TM/ is a surface glycoprotein involved in the regulation of blood coagulation and fibrinolysis. TM has been reported to be expressed in variety of tumors. The purpose of this study was to evaluate the concentration of soluble TM in patients with planoepithelial lung cancer. Study group consisted of 33 patients aged 51 years in IB /15/ and IIIB /18/ stage of cancer and 20 adults as control. Concentration of TM in plasma with ELISA method was performed. Mean level of TM in lung cancer patients was 4.98 +/- 0.94 ng/ml and was similar to control--4.60 +/- 0.88 ng/ml. No significant differences were found between patients with IB and IIIB stage of cancer.