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An Ex vivo Culture System to Study Thyroid Development
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[Mother thyroid status and development of enzymes of initial and final phases of carbohydrate hydrolysis]

L S Kuchkareva1, K R Rakhimov

  • 1Institute of Physiology and Biophysics, Uzbekistan Republic Acad. Sci., 700095, Tashkent, 1 Niyazova St., Uzbekistan.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|September 29, 2001
PubMed

The daily treatment of a lactating mother with thyroxine 50 micrograms/100 g b.w. from the first to 21st day of lactation resulted in an increase of the thyroxine level in serum and earlier induction of alpha-glycosidases (pancreatic alpha-amylase and enteral maltase, saccharase) and in the earlier repression of beta-galactosidases (intestinal lactase) in rats. In contrast, sucklings fed by hypothyroid mothers showed a low level of thyroxine and a delayed induction of alpha-glucosidases but ameliorated the repression of lactase.

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