Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Model-based administration of inhalation anaesthesia. 1. Developing a system model.

J G Lerou1, L H Booij

  • 1Institute for Anaesthesiology, University of Nijmegen, The Netherlands.

British Journal of Anaesthesia
|September 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium].

Der Anaesthesist·2008
Same author

Comparison of the effects and disposition kinetics of lidocaine and (+/-)prilocaine in patients undergoing axillary brachial plexus block during day case surgery.

Clinical drug investigation·2008
Same author

Rocuronium: high risk for anaphylaxis?

British journal of anaesthesia·2002
Same author

Is succinylcholine appropriate or obsolete in the intensive care unit?

Critical care (London, England)·2001
Same author

Model-based administration of inhalation anaesthesia. 2. Exploring the system model.

British journal of anaesthesia·2001
Same author

The future of anaesthesiology.

European journal of anaesthesiology·2001
Same journal

Postoperative outcomes in older patients with postoperative delirium in the UK: timing of postoperative delirium screening in the SNAP-3 study. Comment on Br J Anaesth 2026; 136: 1578-87.

British journal of anaesthesia·2026
Same journal

Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia.

British journal of anaesthesia·2026
Same journal

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis.

British journal of anaesthesia·2026
Same journal

Postoperative outcomes in older patients living with frailty and multimorbidity in the UK. Response to Br J Anaesth 2026; 136: 776-7.

British journal of anaesthesia·2026
Same journal

South African Paediatric Surgical Outcomes Study-2 (SAPSOS-2): a prospective multi-centre pre-post study evaluating haemoglobin response to oral iron for iron-deficiency anaemia in children undergoing elective noncardiac surgery.

British journal of anaesthesia·2026
Same journal

Intravenous iron administration and management of adverse events: a systematic review and Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis consensus recommendations.

British journal of anaesthesia·2026
See all related articles

This study introduces a new multiple-gas system model for inhalation anesthesia administration, accurately simulating breathing systems and gas kinetics. The model shows strong agreement with observed data, supporting its mathematical credibility for further research.

Area of Science:

  • Anesthesiology
  • Physiological modeling
  • Respiratory system dynamics

Background:

  • Inhalation anesthesia administration requires precise control of multiple gases.
  • Existing models often simplify breathing systems, limiting accuracy.
  • A comprehensive model is needed to simulate real-world anesthetic delivery.

Purpose of the Study:

  • To develop and validate a multiple-gas system model for inhalation anesthesia.
  • To accurately represent a non-ideal circle-absorber breathing system with a standing bellows ventilator.
  • To describe the kinetics of various gases within the system.

Main Methods:

  • Developed a multiple-gas model incorporating fresh-gas flow rates from basal to total ventilation.
  • Included a realistic circle-absorber breathing system with a standing bellows ventilator.

Related Experiment Videos

  • Empirically matched the model to a specific GMS absorber and 7850 ventilator (Datex-Ohmeda).
  • Simulated gas kinetics (N2, O2, CO2, N2O, anesthetic agents, He) and validated with closed-circuit helium dilution.

    • Main Results:

    • Model predictions for isoflurane wash-in and desflurane/isoflurane uptake closely matched observed data.
    • Continuous monitoring of total gas pressures and mass balance calculations supported model accuracy.
    • Simulation of alveolar space measurement via helium dilution confirmed mathematical credibility.

    Conclusions:

    • The developed multiple-gas system model accurately simulates inhalation anesthesia administration.
    • The model's ability to predict gas kinetics and uptake validates its mathematical integrity.
    • This model warrants further investigation for clinical and research applications in anesthesia.