Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Depression in multiple sclerosis: relationship to planning ability.

P A Arnett1, C I Higginson, J J Randolph

  • 1Pennsylvania State University, Psychology Department, University Park 16802-3105, USA. paa6@psu.edu

Journal of the International Neuropsychological Society : JINS
|September 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A much needed metric: Defining reliable and statistically meaningful change of the oral version Symbol Digit Modalities Test (SDMT).

Multiple sclerosis and related disorders·2021
Same author

Tired of not knowing what that fatigue score means? Normative data of the Modified Fatigue Impact Scale (MFIS).

Multiple sclerosis and related disorders·2020
Same author

Corrigendum to: A new look at an old test: Normative data of the symbol digit modalities test-Oral version [Multiple Sclerosis and Related Disorders 43 (2020) 102154].

Multiple sclerosis and related disorders·2020
Same author

A new look at an old test: Normative data of the symbol digit modalities test -Oral version.

Multiple sclerosis and related disorders·2020
Same author

Sex and psychiatric comorbidity correlates of the premonitory urge for tic scale in youth with persistent tic disorders.

Journal of neural transmission (Vienna, Austria : 1996)·2020
Same author

Is the outpatient management of acute diverticulitis safe and effective? A systematic review and meta-analysis.

Techniques in coloproctology·2019
Same journal

Preliminary evaluation of a novel Brief Mathematics Achievement Test as a proxy for measuring quality of education in culturally and linguistically diverse populations.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

Cognitive dispersion in the Alzheimer's disease spectrum.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

Neuropsychological criteria for Mild Cognitive Impairment (MCI) best identify neuroimaging-based risk profiles: A Department of Defense/Alzheimer's Disease Neuroimaging Initiative study.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

King-Devick test normative values and reliable change analysis for elite Finnish adolescent ice hockey athletes.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

Age-varying associations between parent-reported executive function and internalizing/externalizing problems in children with neurofibromatosis type 1: an integrative analysis of data from nine institutions.

Journal of the International Neuropsychological Society : JINS·2026
See all related articles

Depression in multiple sclerosis (MS) patients is linked to impaired executive functions. Depressed MS patients showed significant deficits in planning tasks, suggesting slowed processing speed and executive skill deficiencies.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Multiple sclerosis (MS) is frequently associated with depression.
  • Executive function deficits, particularly in planning, are observed in MS patients.
  • Depression is known to impact executive task performance.

Purpose of the Study:

  • To investigate the association between depression and planning impairments in MS patients.
  • To compare the planning task performance of depressed versus nondepressed MS patients.
  • To identify cognitive factors contributing to depression in MS.

Main Methods:

  • Utilized the Tower of London (TOL) task to assess planning abilities.
  • Compared performance metrics (moves, time) between depressed and nondepressed MS patient groups.

Related Experiment Videos

  • Conducted regression analyses incorporating TOL and other cognitive task indices.

    • Main Results:

    • Depressed MS patients made significantly more moves and took longer per trial on the TOL task compared to nondepressed patients.
    • Speeded attentional/working memory tasks predicted 25% of the variance in depression scores.
    • The TOL-time/trial index overlapped with attentional/working memory variance, while TOL-moves/trial uniquely predicted 8% of MS depression scores.

    Conclusions:

    • Slowed information processing speed is a core cognitive deficit in depressed MS patients.
    • Deficient nonspeeded central executive skills also contribute to cognitive impairments in depressed MS.
    • These findings highlight the complex interplay between depression and cognitive function in multiple sclerosis.