In vitro study on the effects of silver sulfadiazine on bilirubin binding

Silver sulfadiazine is a new topical antimicrobial agent with a broad spectrum of activity against most bacterial (both gram-positive and gram-negative) and many fungal species. This broad spectrum of activity suggests that silver sulfiazine may be useful in clinical situations which require the inhibition of cutaneous bacterial and/or fungal colonization. The present study was undertaken to determine the effect of this agent on a bilirubin-protein binding. Using chromatographic procedures on artificially jaundiced sera and human serum albumin solutions, we were unable to detect any releast of protein-bound bilirubin by a saturated suspension of silver sulfadiazine.