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DAPD (Emory University/Triangle Pharmaceuticals/Abbott Laboratories).

A H Corbett1, J C Rublein

  • 1The University of North Carolina Hospitals, Department of Pharmacy, Chapel Hill 27514, USA. AHCorbet@unch.unc.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|September 29, 2001
PubMed
Summary

Triangle Pharmaceuticals is developing dioxolane guanosine (DAPD), a novel antiviral agent, for HIV and HBV infections. Clinical trials are underway, and DAPD shows promise as a unique therapeutic option.

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Area of Science:

  • Antiviral drug development
  • Nucleoside analog research
  • Virology

Background:

  • DAPD is a prodrug of dioxolane guanosine, a viral replication inhibitor.
  • It is being developed by Triangle Pharmaceuticals for HIV and HBV infections.
  • DAPD represents a distinct nucleoside series with potential advantages over existing therapies.

Purpose of the Study:

  • To evaluate DAPD as a potential therapy for Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) infections.
  • To assess the safety and efficacy of DAPD through Phase I/II and Phase II clinical trials.

Main Methods:

  • Phase I/II dose-ranging studies for HIV treatment.
  • Planned clinical development for HBV infection.
  • Ongoing Phase II trials scheduled for Q2 2001.

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Main Results:

  • DAPD has received Fast Track designation from the FDA.
  • Preclinical data suggest efficacy in combination therapies for both treatment-naive and treatment-experienced HIV patients.
  • Potential utility against drug-resistant HIV-1 strains.

Conclusions:

  • DAPD is a promising antiviral candidate with potential advantages due to its unique structure.
  • It is being developed in collaboration with Abbott Laboratories.
  • Further clinical evaluation is warranted for HIV and HBV treatment.