Electron microscopic appearance of silver sulfadiazine-treated Enterobacter cloacae

Upon exposure of Enterobacter cloacae silver sulfadiazine, a number of ultrastructural changes involving the cell envelope take place. Foremost among these is a modification of the cell wall from an undulating structure to one which is smooth and has become enlarged. Strains of E. cloacae resistant to silver sulfadiazine do not exhibit these changes.