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Related Experiment Videos

Blood trauma induced by clinically accepted oxygenators.

S Kawahito1, T Maeda, M Yoshikawa

  • 1Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Houston, Texas, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 29, 2001
PubMed
Summary

This study introduces a new method to test oxygenator hemolysis during cardiopulmonary bypass (CPB). The Medtronic Affinity oxygenator showed the lowest hemolysis, indicating better biocompatibility compared to others tested.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Science
  • Materials Science

Background:

  • Hemolysis is a critical complication in cardiopulmonary bypass (CPB), extracorporeal membrane oxygenation (ECMO), and percutaneous cardiopulmonary support (PCPS).
  • The hemolytic properties of clinical oxygenators are not well characterized, necessitating standardized evaluation.

Purpose of the Study:

  • To develop and validate a specialized hemolysis test protocol for oxygenators.
  • To comparatively assess the hemolytic performance of four clinically available oxygenators during CPB.

Main Methods:

  • A novel hemolysis test protocol for oxygenators was developed, adhering to ASTM standards.
  • Four oxygenators (Medtronic Affinity, Cobe Optima, Terumo Capiox SX25, Bard Quantum) were evaluated using calf blood at a fixed flow rate (5 L/min).

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  • The Normalized Index of Hemolysis for Oxygenators (NIHO) was calculated, with artifact effects from pumps subtracted.

    • Main Results:

    • The Medtronic Affinity oxygenator exhibited the lowest NIHO value (0.0116 ± 0.0017 g/100 L), indicating minimal hemolysis.
    • Hemolysis increased in the order: Affinity < Optima (0.0270 ± 0.0038) < Capiox (0.0335 ± 0.0028) < Quantum (0.0416 ± 0.0015 g/100 L).
    • A strong correlation was observed between NIHO values and blood chamber pressure drop.

    Conclusions:

    • The developed evaluation method effectively compares the biocompatibility of different oxygenators for CPB.
    • The Medtronic Affinity demonstrated superior performance regarding hemolysis compared to the other evaluated oxygenators.
    • This protocol provides a standardized approach for assessing oxygenator-induced hemolysis in clinical settings.