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Do different dialytic techniques have different atherosclerotic and antioxidant activities?
S Biasioli1, R Schiavon, L Petrosino
1Nephrology and Dialysis Unit, Legnano Hospital, Italy.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 29, 2001
Summary
Paired filtration dialysis (PFD) shows the best acute results in improving atherosclerosis and antioxidant activity in chronic hemodialysis patients. PFD effectively normalized atherosclerotic and antioxidant indices after a single session, unlike other dialytic techniques.
Area of Science:
- Nephrology
- Biochemistry
- Cardiovascular Medicine
Background:
- Chronic hemodialysis (HD) patients exhibit altered atherosclerosis and antioxidant status.
- Dialytic techniques may differentially impact these metabolic parameters.
Purpose of the Study:
- To compare the chronic effects of bicarbonate dialysis (BHD), acetate-free biofiltration (AFB), hemodiafiltration (HDF), and paired filtration dialysis (PFD) on atherosclerosis and antioxidant activity.
- To evaluate the efficacy of different dialytic techniques in normalizing key biochemical indices.
Main Methods:
- Development of an atherosclerotic index (AI) and an antioxidant activity index (AOAI) using plasma and erythrocyte parameters.
- Calculation of a defense index (DI) as AOAI - AI.
- Measurement of indices in 20 controls and 51 chronic HD patients undergoing BHD, AFB, HDF, or PFD for at least 12 months, before, during, and after a dialysis session.
Main Results:
- HD patients showed significantly higher AI and lower AOAI compared to controls.
- Paired filtration dialysis (PFD) demonstrated the most favorable acute results, with indices approaching normal values post-session.
- Other techniques like BHD, AFB, and HDF showed less pronounced improvements in AI and AOAI.
Conclusions:
- Paired filtration dialysis (PFD) appears to be the most effective dialytic technique for acutely improving markers of atherosclerosis and antioxidant activity in chronic hemodialysis patients.
- The developed indices (AI, AOAI, DI) provide a quantitative measure to assess the impact of different dialytic strategies on oxidative stress and atherogenesis.