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Updated: Aug 1, 2026

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
The alkaloids of Artabotrys uncinatus
T J Hsieh1, F R Chang, Y C Chia
1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Abstract:
A novel type of alpha,beta-butenolide alkaloid, uncinine (1), two novel oxoaporphines, artabonatine C (2) and artabonatine D (3), a new oxazoloaporphine, artabonatine E (4), and a new 7,7'-bisdehydroaporphine, artabonatine F (5), along with 25 known alkaloids, were isolated from Artabotrys uncinatus. The structures of 1-5 were determined using NMR and mass spectral data. Atherospermidine and squamolone exhibited cytotoxicity against hepatocarcinoma cancer cell lines (Hep G(2) and 2,2,15), and the activity of some of the alkaloids in an antithrombin assay is also discussed.
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