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New multiflorane-type triterpenoid acids from Sandoricum indicum.
T Tanaka1, T Koyano, T Kowithayakorn
1Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Journal of Natural Products
|September 29, 2001
Summary
Three new triterpenoid acids from Sandoricum indicum showed potential anticancer activity. These compounds, sandorinic acids A-C, were tested against tumor cell lines and on lymphocyte proliferation.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Organic Chemistry
Background:
- Sandoricum indicum is a plant used in traditional medicine.
- Triterpenoids are a class of natural compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new triterpenoid acids from Sandoricum indicum.
- To evaluate the biological activity of isolated compounds against cancer cell lines and lymphocytes.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of new compounds via spectral data interpretation (NMR, MS).
- In vitro evaluation of cytotoxic activity against tumor cell lines and effects on lymphocyte proliferation.
Main Results:
- Three new 12beta-hydroxymultiflorane triterpenoid acids, sandorinic acids A-C, were isolated.
- Five known triterpenes were also identified.
- Compounds 1-8 were evaluated for their biological activities.
Conclusions:
- The study successfully isolated and identified novel triterpenoid acids from Sandoricum indicum.
- The isolated compounds exhibited varying degrees of activity against tumor cell lines and on lymphocyte proliferation, suggesting potential therapeutic applications.