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11-Demethylcyclosporins exhibit a single conformation in methanol and dimethylsulfoxide

P Sedmera¹, A Jegorov, M Buchta

¹Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. sedmera@biomed.cas.cz

The Journal of Peptide Research : Official Journal of the American Peptide Society

|September 29, 2001

Abstract:

NMR studies showed that 11-demethylcyclosporin A (cyclosporin E) and 11-demethylcyclosporin B exist as single species both in polar and nonpolar solvents. They adopt the same conformation that was found in the solid state.

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