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Configurational analysis and relative binding affinities of 16-methyl-5alpha-androstane derivatives

P Tapolcsányi1, J Wölfling, I Tóth

  • 1Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.

Steroids
|September 29, 2001
PubMed

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Constitutional Isomers of Alkanes

Organic compounds of the same molecular formula can have different structural formulas called constitutional isomers, and the phenomenon is known as constitutional isomerism. Alkanes with four or more carbons showing multiple structures with the same molecular formula thereby exhibit constitutional isomerism.
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Conformations of Cycloalkanes

Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that was based on the...
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This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
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For example, in...
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Disubstituted Cyclohexanes: cis-trans Isomerism

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Relative Stabilities of Alkenes

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