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Recent developments in computational proteomics.

E T. Maggio1, K Ramnarayan

  • 1Structural Bioinformatics, 92127, Tel: +1 858 675 2400 fax: +1 858 618 1040, San Diego, CA, USA

Drug Discovery Today
|September 29, 2001
PubMed
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Protein structure mapping is revolutionizing drug discovery. Advanced computational methods provide accurate protein models, accelerating the development of novel protein therapeutics and drugs.

Area of Science:

  • Genomics and Proteomics
  • Structural Biology
  • Computational Biology

Background:

  • Human genome mapping completion enables focus on protein function.
  • Understanding proteins is crucial for biological pathways and disease research.
  • Exploiting protein roles is key for developing protein therapeutics and drugs.

Purpose of the Study:

  • To highlight the impact of protein structure in the post-genomic era.
  • To emphasize the role of structural information in rational experimental design.
  • To discuss advancements in protein structure data and computational modeling.

Main Methods:

  • Leveraging large-scale three- and four-dimensional protein structural information.
  • Utilizing new computational methodologies for protein structure modeling.

Related Experiment Videos

  • Comparing modeled protein structures with crystal structures.

    • Main Results:

    • Improvements in protein structure quality, availability, and utility are driving innovation.
    • Protein structure analysis significantly impacts drug discovery and optimization.
    • Computational methods now produce modeled structures comparable to crystal structures.

    Conclusions:

    • Widespread use of protein structure is essential for rational design in the post-genomic era.
    • Advancements in protein structural data and computational modeling accelerate therapeutic development.
    • Protein-based drug discovery is being revolutionized by structural insights and modeling techniques.