[Role of cytokines in chronic gastritis by Helicobacter pylori]
1Instituto de Gastroenterología de Cuba.
Abstract:
Helicobacter pylori is a curved, gram negative bacterium that inhabits only the gastric mucous membrane. Since its discovery and characterization, it has been related to the physiopathology of gastroduodenal diseases, including gastritis, peptic ulcers, gastric carcinoma and MALT lymphoma. This has resulted in numerous hypotheses that try to explain the different events that take place during the inflammation. The bacterium Settler, characterized by a marked infiltration of inflammatory cells (neutrophils, monocytes, linfocytes, etc.) which, after being activated, liberate locally various chemical mediators, which cause tissue damage. Among these, the cytokines are important mediators in this process. We have revised the literature related to the various biological functions of cytokines in tissue damage of the gastric mucosa.
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology


