Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reentry in a morphologically realistic atrial model.

E J Vigmond1, R Ruckdeschel, N Trayanova

  • 1Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA.

Journal of Cardiovascular Electrophysiology
|October 2, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

State of the Art of Artificial Intelligence in Clinical Electrophysiology in 2025: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), and the ESC Working Group on E-Cardiology.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2025
Same author

Digital twins in medicine.

Nature computational science·2024
Same author

Mechanisms linking electrical alternans and clinical ventricular arrhythmia in human heart failure.

Heart rhythm·2016
Same author

Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology.

Progress in biophysics and molecular biology·2014
Same author

Accelerating cardiac bidomain simulations using graphics processing units.

IEEE transactions on bio-medical engineering·2012
Same author

Modulation of shock-end virtual electrode polarisation as a direct result of 3D fluorescent photon scattering.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
Same journal

Pulsed Field Ablation Is Associated With Fewer Post-Procedural Pericardial Inflammatory Symptoms Compared With Radiofrequency Ablation.

Journal of cardiovascular electrophysiology·2026
Same journal

Single-Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2026
Same journal

Relationship Between Nonuniform Isochrone-Area in Late Activation Mapping and Arrhythmogenic Substrates Related to Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2026
Same journal

Clinical Utility of Tissue Proximity Indication With a Variable-Loop Circular Catheter for Pulmonary Vein Isolation.

Journal of cardiovascular electrophysiology·2026
Same journal

Impact of Carina Width on Re-Ablation Rate of Atrial Fibrillation After Primary Cryoballoon-Ablation.

Journal of cardiovascular electrophysiology·2026
Same journal

Mediastinal Air Entrapment During Extravascular ICD Implantation: A Preventable Cause of Elevated Shock Impedance.

Journal of cardiovascular electrophysiology·2026
See all related articles

This study used a computer model to identify how atrial anatomy influences reentry in atrial fibrillation. Specific structures like the coronary sinus and crista terminalis stabilize circuits, aiding ablation strategies.

Area of Science:

  • Cardiac Electrophysiology
  • Computational Modeling
  • Anatomy

Background:

  • Atrial fibrillation is a common arrhythmia requiring precise identification of reentrant pathways.
  • Complex atrial morphology presents challenges in pinpointing these pathways during ablation procedures.

Purpose of the Study:

  • To investigate the influence of specific anatomical structures on the induction and maintenance of reentrant circuits in the atria.
  • To enhance understanding of atrial fibrillation mechanisms through computational modeling.

Main Methods:

  • Development of a computationally efficient, morphologically realistic computer model of the atria.
  • Incorporation of key structural features: interatrial connections, 3D fiber orientation, crista terminalis (CT) and pectinate muscles, and venous/AV valve openings.

Related Experiment Videos

  • Induction of reentries and assessment of structural roles by selective removal of components.

    • Main Results:

    • Reentries were successfully induced near venous openings, coronary sinus, and right atrial free wall.
    • The muscular sheath of the coronary sinus was identified as a pathway and stabilizer for reentrant circuits.
    • Poor trans-CT coupling was found to stabilize flutter circuits.
    • Left atrial wall thickness significantly impacts electrical activity propagation.
    • Vena cavae openings act as natural anchors facilitating reentry initiation.

    Conclusions:

    • The coronary sinus muscular sheath and poor trans-CT coupling are crucial for stabilizing reentrant circuits.
    • Atrial wall thickness, particularly in the left atrium, plays a significant role in electrical propagation.
    • Anatomical features like vena cavae openings facilitate reentry induction, offering targets for ablation strategies.