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Enzymatic glycosylation of lincomycin
L Weignerová1, J Spizek, L Najmanová
1Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.
Bioscience, Biotechnology, and Biochemistry
|October 2, 2001
Abstract:
Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean alpha-mannosidase to produce 7-O-alpha-D-mannopyranosyl-lincomycin (2).