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Aminophylline reversal of antihypertensive agent toxicity
R J Roberge1, M L Rossetti, J M Rosetti
1Department of Emergency Medicine and the Internal Medicine Residency Program, St Francis Medical Center, Pittsburgh, PA 15202, USA.
Abstract:
Hypotension occurred following a combined beta blocker (atenolol), angiotensin converting enzyme inhibitor (quinapil) and selective serotonin reuptake inhibitor (fluvoxamine) overdose. In another instance heart block and hypotension was noted in association with a diltiazem and atenolol adverse interaction. Crystalloid infusion was ineffective in both cases, but toxicity was rapidly reversed with aminophylline administration. Aminophylline's recognized inotropic and chronotropic properties make it a potentially valuable therapeutic agent in the treatment of antihypertensive medication toxicity.
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