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Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis
P Purucker1, H Mertes, J M Goodson
1Department of Periodontology and Synoptic Dentistry, University Hospital Charité, Humboldt-University at Berlin, Germany. peter.purucker@charite.de
Journal of Periodontology
|October 2, 2001
Summary
Adjunctive local tetracycline fibers and systemic amoxicillin/clavulanic acid showed similar clinical outcomes for generalized aggressive periodontitis (GAgP) patients after scaling and root planing (SRP). Both treatments effectively reduced probing depth and improved clinical attachment levels over nine months.
Area of Science:
- Periodontology
- Pharmacology
- Microbiology
Background:
- Generalized aggressive periodontitis (GAgP) treatment often involves systemic antibiotics.
- The efficacy of adjunctive local tetracycline fibers in GAgP has not been previously reported.
- This study compares local tetracycline fibers versus systemic antibiotics as adjuncts to scaling and root planing (SRP) in GAgP patients.
Purpose of the Study:
- To compare the clinical outcomes of adjunctive local tetracycline fiber therapy versus systemic amoxicillin/clavulanic acid in patients with GAgP.
- To evaluate the effectiveness of these treatments following initial periodontal therapy and SRP.
Main Methods:
- Thirty GAgP patients were randomized into two groups after SRP: SRP + local tetracycline fiber (TCF) or SRP + systemic amoxicillin/clavulanic acid (AUG).
- Clinical parameters including probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were assessed at baseline and up to 54 weeks post-treatment.
- Treatments were administered three months after SRP.
Main Results:
- Both SRP + TCF and SRP + AUG groups demonstrated significant reductions in PD and gains in CAL from baseline to 54 weeks.
- No statistically significant differences were observed between the two groups in terms of pocket reduction or CAL gain.
- While BOP significantly decreased in both groups, the reduction was notably greater in the SRP + AUG group at week 54.
Conclusions:
- Local delivery of tetracycline via fibers and systemic administration of amoxicillin/clavulanic acid yield comparable clinical results in GAgP patients.
- Both treatment modalities, when used as adjuncts to SRP, effectively manage GAgP over a nine-month period.
- Systemic amoxicillin/clavulanic acid may offer a greater reduction in bleeding sites compared to local tetracycline fibers.