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Paget's disease of the vulva: the Radiumhemmet series 1975-1990
H. Baehrendtz1, N. Einhorn, F. Pettersson
1Department of Obstetrics and Gynaecology, Nacka Hospital, Nacka; Departments of Gynaecological Oncology, Radiumhemmet, Tumour Pathology, Karolinska Hospital, Stockholm, Sweden.
Abstract:
Twenty-eight patients with a diagnosis of 'extramammary Paget's disease of the vulva' were referred to the Radiumhemmet, Karolinska Sjukhuset, Stockholm, during the period 1975-1990. A clinical and histopathologic retrospective review was undertaken. Six patients had associated malignancies (21.4%). The disease was considered primary invasive in three cases, whereas three patients later developed an invasive cancer. Surgery-local resection, hemivulvectomy or vulvectomy-was performed in 24 cases. Twelve patients, in which surgery was supposed to be radical with respect to free margins, had a significantly longer recurrence-free survival than 12 patients in which the surgical margins were dubious.