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The mechanism of action of DNA photolyases
T Carell1, L T Burgdorf, L M Kundu
1Philipps-University Marburg, Department of Chemistry, Hans-Meerwein-Street, D-35032 Marburg, Germany. carell@mailer.uni-marburg.de
Current Opinion in Chemical Biology
|October 2, 2001
Abstract:
Structural analysis, biochemistry and model studies have provided new insights into the mechanism of action of photolyases. The light-driven electron and energy transfer events that lead to the photolyase-catalyzed repair of lethal, mutagenic and carcinogenic UV-light-induced DNA lesions have all been examined in the past few years.