Related Experiment Videos
Adenosylmethionine as a source of 5'-deoxyadenosyl radicals
M Fontecave1, E Mulliez, S Ollagnier-de-Choudens
1Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques, DBMS-CB, CEA/CNRS/Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble, Cedex 09, France. mfontecave@cea.fr
Current Opinion in Chemical Biology
|October 2, 2001
Abstract:
The combination of an iron-sulfur cluster and S-adenosylmethionine provides a novel mechanism for the initiation of radical catalysis in an unanticipated variety of metabolic processes. Molecular details of the cluster-mediated reductive cleavage of S-adenosylmethionine to methionine and, presumably, a 5'-deoxyadenosyl radical are the targets of recent studies.