Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fat hedgehogs, slower or richer?

M van Den Heuvel1

  • 1MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK, OX1 3QX. marcel.vandenheuvel@human-anatomy.oxford.ac.uk

Science'S STKE : Signal Transduction Knowledge Environment
|October 2, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preconditions Contributing to Interprofessional Collaboration in the Management of COPD in Primary Care: A Scoping Review.

International journal of integrated care·2025
Same author

Real-world outcomes with durvalumab after chemoradiotherapy in patients with unresectable stage III NSCLC: interim analysis of overall survival from PACIFIC-R.

ESMO open·2024
Same author

A revolving research fund to study efficient use of expensive drugs: big wheels keep on turning.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

The clinical effectiveness of the COPDnet integrated care model.

Respiratory medicine·2020
Same author

Effects of checkpoint inhibitors in advanced non-small cell lung cancer at population level from the National Immunotherapy Registry.

Lung cancer (Amsterdam, Netherlands)·2020
Same author

Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same journal

Identification of redox-active cell-surface proteins by mechanism-based kinetic trapping.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Image correlation spectroscopy.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Studies of SARM1 uncover similarities between immune and neuronal responses to danger.

Science's STKE : signal transduction knowledge environment·2007
Same journal

A discrete signaling function for an inositol pyrophosphate.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Putting on the RITz.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Type I interferons as anti-inflammatory mediators.

Science's STKE : signal transduction knowledge environment·2007
See all related articles

Hedgehog (Hh) protein acylation, including cholesterol and palmitic acid addition, controls its developmental patterning activity. Differences in acylation impact sonic hedgehog (Shh) and Drosophila Hh activity.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Protein Biochemistry

Background:

  • Hedgehog (Hh) proteins are crucial signaling molecules in embryonic development.
  • Hh activity is regulated by post-translational modifications like cleavage and lipidation.
  • Acylation, the addition of fatty acids, is a key modification affecting Hh function.

Purpose of the Study:

  • To elucidate how acylation of Hedgehog (Hh) protein impacts its biological activity.
  • To compare the functional consequences of acylation between vertebrate sonic hedgehog (Shh) and Drosophila Hh.

Main Methods:

  • Analysis of Hh protein structure and function.
  • Investigating post-translational modifications, specifically acylation.
  • Comparative studies of Shh and Drosophila Hh.

Related Experiment Videos

Main Results:

  • Acylation significantly modulates the activity of Hedgehog proteins.
  • Distinct differences in acylation-dependent activity exist between Shh and Drosophila Hh.
  • Specific fatty acid modifications influence Hh signaling pathways.

Conclusions:

  • Acylation is a critical regulatory mechanism for Hedgehog protein function in development.
  • Understanding these modifications provides insights into conserved and divergent roles of Hh signaling.
  • Further research into Hh lipidation can inform therapeutic strategies targeting developmental processes.