Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrophysiological correlations with postjunctional supersensitivity.

W W Fleming, P R Urquilla, D A Taylor

    Federation Proceedings
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction: The biology of environmental stress: molecular biomarkers in Sydney rock oysters (Saccostrea glomerata).

    Environmental science. Processes & impacts·2016
    Same author

    The biology of environmental stress: molecular biomarkers in Sydney rock oysters (Saccostrea glomerata).

    Environmental science. Processes & impacts·2016
    Same author

    Pulmonary veno-occlusive disease associated with hypertrophic cardiomyopathy.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Building new hearts: a review of trends in cardiac tissue engineering.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
    Same author

    Degree of training and the novelty transfer effect.

    Memory & cognition·2013
    Same author

    Severe tracheobronchomalacia after prolonged intubation of multitrauma patient.

    Case reports in surgery·2012

    Partial depolarization, not adrenergic receptor changes, drives postjunctional supersensitivity in smooth and cardiac muscle. This occurs after nerve interruption, bringing the resting membrane potential closer to excitation threshold.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Physiology

    Background:

    • Postjunctional supersensitivity is a key adaptation following denervation or decentralization of muscle.
    • The underlying mechanisms, particularly the role of membrane potential changes versus receptor alterations, require further elucidation.

    Purpose of the Study:

    • To investigate the role of partial depolarization in the development of postjunctional supersensitivity in the vas deferens and atrium.
    • To determine whether changes in adrenergic receptors contribute significantly to this phenomenon.

    Main Methods:

    • Microelectrode recordings were used to measure membrane potential changes in guinea pig vas deferens and atria after denervation/decentralization.
    • Analysis of junction potentials in the vas deferens was performed.

    Related Experiment Videos

  • Correlation analysis between membrane potential and supersensitivity was conducted.

    • Main Results:

    • A partial depolarization of approximately 10 mV was observed in the vas deferens post-denervation/decentralization.
    • The time course of depolarization correlated with the development of supersensitivity.
    • Analysis indicated that adrenergic receptor changes are not a significant factor in vas deferens supersensitivity.
    • A strong correlation was found between supersensitivity and partial depolarization in guinea pig atria.

    Conclusions:

    • Partial depolarization is a critical event in the development of postjunctional supersensitivity in smooth and cardiac muscle.
    • Chronic interruption of innervation may alter calcium binding, leading to depolarization and increased excitability.