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Related Concept Videos

The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Atomic Nuclei: Nuclear Spin01:08

Atomic Nuclei: Nuclear Spin

All atomic particles possess an intrinsic angular momentum, or 'spin'. Electrons, protons, and neutrons each have a spin value of ½, although protons and neutrons in nuclei may have higher half-integer spins owing to energetic factors.
Atomic nuclei have a net nuclear spin, , which can have an integer or half-integer value. In atomic nuclei, the spins of protons are paired against each other but not with neutrons, and vice versa. Consequently, an even number of protons does not contribute to...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Hereditary ataxia. An unfolded protein.

Lancet (London, England)·2002
Same author

Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.

Neurobiology of disease·2001
Same author

RNA targets of the fragile X protein.

Cell·2001
Same author

SCA1 molecular genetics: a history of a 13 year collaboration against glutamines.

Human molecular genetics·2001
Same author

Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice.

The American journal of pathology·2001
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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.

Human molecular genetics·2001

Related Experiment Video

Updated: Jul 20, 2026

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy
08:03

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy

Published on: April 13, 2022

Qs in the nucleus.

H T Orr1

  • 1Institute of Human Genetics, University of Minnesota, Mayo Mail Code 206, Minneapolis, MN 55455, USA.

Neuron
|October 3, 2001
PubMed
Summary

Polyglutamine diseases, a group of neurodegenerative disorders, are linked to toxic mutant protein accumulation. This study reveals how SCA7 causes retinal degeneration by disrupting the CRX transcription factor in photoreceptors.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Polyglutamine diseases encompass over nine neurodegenerative disorders.
  • The pathological mechanism involves the accumulation of mutant proteins with toxic gain-of-function properties within the cell nucleus.

Discussion:

  • This research investigates the cell-specific pathology of polyglutamine diseases.
  • The study links Spinocerebellar Ataxia Type 7 (SCA7)-induced retinal degeneration to a specific molecular event.

Key Insights:

  • Mutant protein accumulation in the nucleus is central to polyglutamine disease pathology.
  • SCA7-induced retinal degeneration is specifically associated with the disruption of CRX, a transcription factor crucial for photoreceptor function.

Outlook:

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Using Computer Vision Libraries to Streamline Nuclei Quantification
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Using Computer Vision Libraries to Streamline Nuclei Quantification

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Related Experiment Videos

Last Updated: Jul 20, 2026

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy
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Study of Protein Dynamics via Neutron Spin Echo Spectroscopy

Published on: April 13, 2022

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
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Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

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Using Computer Vision Libraries to Streamline Nuclei Quantification
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  • Understanding cell-specific pathology is key to developing targeted therapies for neurodegenerative disorders.
  • Further research into the CRX pathway could reveal new therapeutic strategies for SCA7 and related polyglutamine diseases.