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Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis
1Department of Oriental Pharmacy, College of Pharmacy and Center of Oriental Medicinal Science, Wonkwang University, Chonbuk, 570-749, Iksan City, South Korea.
Summary
Acanthopanax senticosus root (ASR) significantly inhibited anaphylaxis by reducing histamine release and tumor necrosis factor-alpha production. This study suggests ASR has potent anti-anaphylactic activity.
Area of Science:
- Pharmacology
- Immunology
- Natural Products
Background:
- Mast cells are key mediators in anaphylaxis.
- Chemical mediators released by mast cells drive anaphylactic reactions.
Purpose of the Study:
- To investigate the anti-anaphylactic effects of Acanthopanax senticosus root (ASR).
- To evaluate ASR's impact on mast cell-dependent anaphylaxis.
Main Methods:
- ASR's effect on compound 48/80-induced systemic anaphylactic shock was assessed.
- Histamine release from rat peritoneal mast cells was measured.
- Passive cutaneous anaphylaxis and tumor necrosis factor-alpha production were evaluated.
Main Results:
- ASR inhibited systemic anaphylactic shock by 50% at 1.0 g/kg.
- ASR dose-dependently reduced histamine release and tumor necrosis factor-alpha production.
- ASR inhibited passive cutaneous anaphylaxis by 53.17%.
Conclusions:
- ASR demonstrates significant anti-anaphylactic properties.
- ASR effectively modulates key mediators involved in anaphylaxis.