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Microarrays for studying the host transcriptional response to microbial infection and for the identification of host
D Yowe1, W J Cook, J C Gutierrez-Ramos
1Millennium Pharmaceuticals, Cambridge, MA 02139, USA. yowe@mpi.com
Abstract:
It is essential to understand the molecular basis of a host's response to microbial infection so that disease and tissue damage can be prevented. Modulation of host RNA expression is a critical set of molecular changes that occur upon infection. Global analysis of gene expression should provide an understanding of host RNA transcriptional changes that occur upon host-pathogen interaction. This series of articles focuses on the use of microarrays for analyzing the transcriptional response of a host to microbial infection and for drug target identification.
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