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Published on: March 8, 2012
DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions
S Pöhlmann1, G J Leslie, T G Edwards
1Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Journal of Virology
|October 3, 2001
Abstract:
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.
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