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Short-term sexual function after prostate brachytherapy.

G S Merrick1, K Wallner, W M Butler

  • 1Schiffler Cancer Center, Wheeling Hospital, 1 Medical Park, Wheeling, WV 26003-6300, USA. schifonc@wheelinghosp.com

International Journal of Cancer
|October 3, 2001
PubMed
Summary
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Prostate brachytherapy using iodine-125 or palladium-103 maintained sexual function in most patients. Sildenafil was effective for erectile dysfunction, with 76.5% achieving intercourse capability.

Area of Science:

  • Urology
  • Oncology
  • Radiation Oncology

Background:

  • Low-risk prostate cancer treatment often involves brachytherapy.
  • Assessing sexual function post-treatment is crucial for quality of life.

Purpose of the Study:

  • To evaluate sexual function in patients with low-risk prostate cancer treated with brachytherapy.
  • To compare outcomes between iodine-125 and palladium-103 isotopes.

Main Methods:

  • Phase III prospective randomized trial.
  • 34 patients with low-risk prostate cancer (PSA ≤ 10, Gleason ≤ 6, Stage T1/T2).
  • International Index of Erectile Function (IIEF) scores and side effect documentation.

Main Results:

  • No significant difference in IIEF scores between iodine-125 and palladium-103.

Related Experiment Videos

  • 35% experienced severe erectile dysfunction (IIEF < 6).
  • 65% maintained sexual function without medication; 76.5% with sildenafil support.

    • Conclusions:

    • Prostate brachytherapy is associated with significant rates of sexual dysfunction.
    • Sildenafil is an effective treatment for post-brachytherapy erectile dysfunction.
    • Most patients can achieve intercourse capability with or without pharmacologic support.