Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Severe staphylococcal pneumonia in children].

Y Gillet1, B Issartel, P Vanhems

  • 1Service d'urgences et de réanimation pédiatriques, Hôpital Edouard-Herriot, 5, place d'Arsonval, 69437 Lyon, France. yvesgil@yahoo.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|October 5, 2001
PubMed
Summary

Severe staphylococcal pneumonia in children is linked to Panton and Valentine leukotoxin (PVL) production by Staphylococcus aureus. This toxin causes necrotizing pneumonia with high mortality, often following viral infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Vaccines and vaccination against human papillomaviruses in 2008].

Virologie (Montrouge, France)·2022
Same author

Determinants of COVID-19 vaccine hesitancy in French hospitals.

Infectious diseases now·2021
Same author

Recommendations of the AFU Infectious Diseases Committee on the prevention, diagnosis and treatment of infections of endo-ureteral equipment.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2021
Same author

Disc diffusion AST automation: one of the last pieces missing for full microbiology laboratory automation.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
Same author

[Spider bite or infection caused by Panton Valentine leucocidin-producing Staphylococcusaureus?]

Annales de dermatologie et de venereologie·2019
Same author

[Erratum to "Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies" [Med. Mal. Infect. 49 (2019) 296-317]].

Medecine et maladies infectieuses·2019

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pulmonology

Context:

  • Staphylococcus aureus can cause severe pneumonia, particularly in children.
  • Panton and Valentine leukotoxin (PVL) is a toxin produced by some S. aureus strains.
  • The clinical features and outcomes of PVL-positive staphylococcal pneumonia were not well-defined.

Purpose:

  • To investigate the clinical features of severe staphylococcal pneumonia associated with PVL-producing S. aureus.
  • To compare PVL-positive staphylococcal pneumonia cases with PVL-negative cases.
  • To establish the relationship between PVL production and severe staphylococcal pneumonia.

Summary:

  • A prospective surveillance identified 16 cases of PVL-positive staphylococcal pneumonia among 52 referred cases.

Related Experiment Videos

  • PVL-positive pneumonia occurred in younger, previously healthy patients, often following viral infections.
  • Key features included shock, respiratory distress, hemoptysis, and leucopenia, with a higher mortality rate (75%) compared to PVL-negative cases (47%).

    • Impact:

    • Establishes PVL production as a key factor in severe, necrotizing staphylococcal pneumonia.
    • Suggests viral infections may predispose individuals to S. aureus invasion and subsequent PVL-mediated lung damage.
    • Highlights staphylococcal necrotizing pneumonia as a potentially underdiagnosed entity requiring further research into prognosis and management, especially in pediatric cases.