Related Experiment Videos
[Post-varicella thrombosis and factor V Leiden mutation].
M Moussalem1, R Sacy, N Hakime
1Service de pédiatrie, hématologie-oncologie pédiatrique, hôpital Saint-Georges, BP 166378, Beyrouth 6417, Liban. mirnamou@inco.com.lb
Summary
Varicella infection can rarely lead to thrombosis in children. A case study highlights that Factor V Leiden (FVL) mutation increases this risk, suggesting screening and vaccination for affected children.
Area of Science:
- Pediatric Thrombosis
- Infectious Disease Complications
- Genetic Predisposition to Thrombosis
Background:
- Varicella (chickenpox) is typically benign but can rarely cause thrombosis.
- Factor V Leiden (FVL) mutation is a common inherited thrombophilia.
- This report explores the link between varicella-associated thrombosis and FVL mutation.
Observation:
- An 8-year-old boy presented with leg pain and difficulty walking 15 days post-varicella infection.
- Doppler ultrasound confirmed iliac and femoral vein thrombosis.
- Thrombophilia work-up identified heterozygous Factor V Leiden mutation.
Findings:
- Varicella-associated thrombosis is a rare but serious complication in children.
- Factor V Leiden mutation was detected in the affected child, indicating a genetic predisposition.
- The patient responded well to heparin and oral anticoagulant therapy.
Implications:
- Thrombophilia screening is recommended for children experiencing thrombosis post-varicella.
- Varicella vaccination is supported for children with inherited prothrombotic conditions like FVL mutation.
- Early identification and management can prevent severe outcomes of thrombosis in pediatric varicella cases.