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Plasma glutathione peroxidase activity in the elderly
K Wieczorowska-Tobis1, J Wisniewska, K Korybalska
1PathophYsiology Department, University Medical School, Poznan, Poland. tobis@usoms.poznan.pl
International Urology and Nephrology
|October 5, 2001
Summary
Plasma glutathione peroxidase activity (PGP) may indicate kidney function in the elderly. Lower PGP levels were observed in those with impaired renal function, though not directly correlated with age-related kidney decline.
Area of Science:
- Biochemistry
- Nephrology
- Geriatrics
Background:
- Plasma glutathione peroxidase activity (PGP) has been proposed as a potential biomarker for renal function.
- Previous studies indicated PGP activity is depressed in individuals with impaired renal function.
Purpose of the Study:
- To investigate the hypothesis that plasma PGP activity can assess renal function in elderly individuals.
- To evaluate the relationship between plasma PGP, creatinine clearance (ClCr), and age in a cohort of active, community-dwelling elderly.
Main Methods:
- Plasma PGP activity and creatinine clearance (ClCr) were measured in 65 elderly participants (age range: 65-93 years).
- Participants with advanced renal failure were excluded.
- Statistical analyses were performed to assess correlations between PGP, ClCr, serum creatinine (PCr), and age.
Main Results:
- Plasma PGP activity did not correlate with serum creatinine levels.
- A significant positive correlation was observed between plasma PGP activity and creatinine clearance (r = 0.30, p < 0.01).
- Plasma PGP activity was significantly lower in individuals with ClCr < 70 ml/min/1.73 m2 compared to those with higher ClCr (p < 0.01).
- No correlation was found between ClCr and PGP in subjects with lower ClCr.
- While PGP did not correlate with age, ClCr showed a negative correlation with age (r = -0.24, p < 0.05).
Conclusions:
- Plasma PGP activity decreases with impaired renal function in the elderly.
- The decrease in plasma PGP activity in elderly individuals with impaired renal function does not appear to be directly linked to the age-dependent decline in kidney function.