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Drug-induced otoxicity: current status.

V Palomar García1, F Abdulghani Martínez, E Bodet Agustí

  • 1Department of Oto-Rhino-Laryngology, Hospital Universitario Arnau de Vilanova, Universidad de Lleida, Spain. palomar@cirurgia.udl.es

Acta Oto-Laryngologica
|October 5, 2001
PubMed
Summary
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This review summarizes literature on drug-induced ototoxicity, exploring common ototoxic drugs, their mechanisms, and factors influencing susceptibility. It addresses protective measures and monitoring for hearing loss.

Area of Science:

  • Ototoxicology
  • Pharmacology
  • Audiology

Background:

  • Drug-induced ototoxicity is a significant concern.
  • A comprehensive review of recent literature is needed to consolidate knowledge.

Purpose of the Study:

  • To review and synthesize the literature on drug-induced ototoxicity over the past decade.
  • To answer key questions regarding ototoxic drugs, their effects, and management.

Main Methods:

  • A Medline search was conducted for literature from January 1990 to September 2000.
  • Keywords used were 'clinical ototoxicity'.
  • 414 articles were identified and reviewed.

Main Results:

  • Identified commonly used ototoxic drugs and their sites of action.

Related Experiment Videos

  • Discussed the influence of dose, dosing interval, and age on ototoxicity.
  • Examined human susceptibility, protective substances, and hearing loss monitoring.
  • Conclusions:

    • Ototoxicity varies among individuals and is influenced by multiple factors.
    • Understanding these factors is crucial for managing and potentially preventing drug-induced hearing loss.