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Encapsulated fat necrosis: a case of 'thigh mouse'

S M Azad1, A Cherian, C Raine

  • 1Department of Plastic Surgery, Shotley Bridge General Hospital, Consett, UK.

British Journal of Plastic Surgery
|October 5, 2001
PubMed

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Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...