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A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies

C H Lin1, B J Hare, G Wagner

  • 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Molecular Cell
|October 5, 2001
PubMed
Summary

The IRF-3 binding domain (IBiD) in CBP and p300 coactivators undergoes induced folding upon partner binding. This domain is crucial for integrating signals by CBP and p300, impacting gene expression regulation.

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