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Role of Kozak sequence polymorphism of platelet glycoprotein Ibalpha as a risk factor for coronary artery disease and

C Meisel1, V Afshar-Kharghan, I Cascorbi

  • 1Institute of Clinical Pharmacology, Berlin, Germany.

Journal of the American College of Cardiology
|October 5, 2001
PubMed

Insights

The -5C allele of platelet glycoprotein Ibalpha is a risk factor for coronary artery disease and complications after angioplasty. This finding may improve risk assessment for acute coronary syndromes.

Area of Science:

  • Cardiovascular Genetics
  • Thrombosis and Hemostasis
  • Molecular Cardiology

Background:

  • Platelet glycoprotein (GP) Ib-IX-V receptor complex is vital for arterial thrombus formation.
  • The -5T/C polymorphism in GP Ibalpha is linked to higher receptor density.
  • Understanding GP Ibalpha variants can elucidate thrombosis risk.

Purpose of the Study:

  • To investigate the -5T/C polymorphism of GP Ibalpha as a risk factor for coronary artery disease (CAD).
  • To assess the role of this polymorphism in adverse events following coronary catheter interventions.

Main Methods:

  • Genotyping of 1,000 CAD patients and 1,000 controls for the -5T/C polymorphism using PCR/RFLP.
  • Analysis of 269 patients undergoing PTCA, 103 directional coronary atherectomy, and 278 stenting.
  • 30-day follow-up for composite endpoints including revascularization, myocardial infarction, or death.

Main Results:

  • The -5C allele was significantly more common in patients with acute coronary syndromes (RR 1.43, p=0.02).
  • The -5C allele predicted a higher risk of complications after percutaneous transluminal coronary angioplasty (PTCA) (RR 3.75, p=0.029).

Conclusions:

  • The -5C allele of the GP Ibalpha Kozak polymorphism is a potential risk factor for CAD.
  • This polymorphism may increase the risk of thrombosis-related conditions like acute coronary syndromes and post-PTCA complications.
Abstract

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