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Related Experiment Videos

Age-associated changes in regional aortic pulse wave velocity.

W J Rogers1, Y L Hu, D Coast

  • 1Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA. wrogers@wpahs.org

Journal of the American College of Cardiology
|October 5, 2001
PubMed
Summary

Aging increases aortic pulse wave velocity (PWV) regionally, particularly in the proximal aorta. Phase-contrast MRI (PCMRI) noninvasively measures these age-associated changes in mechanical properties.

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Area of Science:

  • Cardiovascular Physiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Aortic pulse wave velocity (PWV) increases with age.
  • Previous PWV measurements were limited to single locations or comparisons between distant arterial sites.

Purpose of the Study:

  • To noninvasively assess age-associated changes in regional aortic mechanical properties.
  • To utilize phase-contrast magnetic resonance imaging (PCMRI) for this assessment.

Main Methods:

  • Phase-contrast MRI (PCMRI) was used to measure PWV in three aortic segments in 24 volunteers (aged 21-72).
  • Applanation tonometry (TONO) was used for validation, measuring PWV between the carotid and femoral arteries.

Main Results:

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  • PCMRI-derived average PWV correlated well with TONO measurements.
  • Older volunteers (>=55 years) showed significantly higher PWV in the ascending and proximal descending aorta compared to younger volunteers.
  • PWV increased with age, particularly in the proximal aorta, while remaining consistent across locations in younger individuals.

    • Conclusions:

    • In-plane PCMRI enables multi-site PWV determination in a single scan.
    • Age-related regional increases in PWV, especially in the proximal aorta, may stem from elastic fiber fragmentation and altered vascular tone regulation.