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Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
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Factors affecting prostacyclin receptor agonist efficacy in different cell types

Y Kam1, K B Chow, H Wise

  • 1Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, SAR, Hong Kong, China.

Cellular Signalling
|October 5, 2001
PubMed
Summary

Octimibate, a prostacyclin mimetic, shows varying efficacy in stimulating adenylyl cyclase due to tissue-specific responses. Its effectiveness is linked to IP receptor signaling pathways, not Gi-coupled pathways, in different cell types.

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