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Updated: Jul 11, 2026

Quantification of Filamentous Actin (F-actin) Puncta in Rat Cortical Neurons
Published on: February 10, 2016
Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin
P M Okamoto1, C Gamby, D Wells
1Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Abstract:
Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.
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