Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predicting polyposis severity by proctoscopy: how reliable is it?

J Church1, C Burke, E McGannon

  • 1Department of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Diseases of the Colon and Rectum
|October 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis.

Translational psychiatry·2026
Same author

Endometrial cancer prevalence in women with an incidental finding of thickened endometrium.

Irish medical journal·2025
Same author

Arboviruses in UK Armed Forces: a review of historical cases and identification of future threats.

BMJ military health·2025
Same author

Poppers-related maculopathy.

Journal francais d'ophtalmologie·2025
Same author

Is an Online Asynchronous Progressive Resistance Training Programme Feasible for Individuals With Down Syndrome?

Journal of applied research in intellectual disabilities : JARID·2025
Same author

Crying out over spilt milk - Quantifying formula milk waste in a large maternity hospital.

Irish medical journal·2025

Preoperative proctoscopy reliably predicts familial adenomatous polyposis (FAP) severity. Fewer than five rectal adenomas indicate mild disease, while 20 or more suggest severe FAP, guiding surgical decisions.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Genetics

Background:

  • Familial adenomatous polyposis (FAP) necessitates prophylactic colectomy with either ileorectal anastomosis or restorative proctocolectomy.
  • Preoperative rectal polyp counts aid in surgical triage, assessing risks for rectal cancer or completion proctectomy post-ileorectal anastomosis.

Purpose of the Study:

  • To evaluate the reliability of preoperative proctoscopy in predicting FAP severity.
  • To assess the predictive value of proctoscopy for outcomes following ileorectal anastomosis.

Main Methods:

  • Categorized 213 FAP patients into three groups based on preoperative rectal adenoma counts (Group 1: ≤5, Group 2: 6-19, Group 3: ≥20).
  • Defined FAP severity as mild (<1,000 colonic polyps) or severe (>1,000 colonic polyps) at colectomy.

Related Experiment Videos

  • Analyzed patient demographics, symptoms, disease severity, surgical procedures, and outcomes including subsequent proctectomy.

    • Main Results:

    • Patients with ≤5 rectal adenomas typically had mild FAP (86.5%) and generally did well after ileorectal anastomosis with few requiring proctectomy (6.3%).
    • Patients with 6-19 rectal adenomas also often had mild FAP (81.6%), with a slightly higher rate of subsequent proctectomy (5.6%), including for rectal cancer (3.7%).
    • Patients with ≥20 rectal adenomas frequently presented with severe FAP (56.6%), had a higher rate of restorative proctocolectomy (50%), and a significantly increased need for later proctectomy (35.1%), including for cancer (10.8%).

    Conclusions:

    • Preoperative proctoscopy is a valuable tool for stratifying FAP patients by disease severity.
    • Fewer than five rectal adenomas strongly predicts mild disease and favorable outcomes with ileorectal anastomosis.
    • Twenty or more rectal adenomas indicate severe disease, necessitating careful consideration of surgical options and potential for future proctectomy.