Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracellular control of cell size.

I J Conlon1, G A Dunn, A W Mudge

  • 1MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London WC1E 6BT, UK. i.conlon@ucl.ac.uk

Nature Cell Biology
|October 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rediscovering contact inhibition in the embryo.

Journal of microscopy·2013
Same author

Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody.

Nature: New biology·2010
Same author

Specificity of anti-theta sera in cytotoxicity and functional tests on T lymphocytes.

Nature: New biology·2010
Same author

Quantifying cell-matrix adhesion dynamics in living cells using interference reflection microscopy.

Journal of microscopy·2008
Same author

Alignment of myoblasts on ultrafine gratings inhibits fusion in vitro.

The international journal of biochemistry & cell biology·2002
Same author

Phenotype modulation in non-adherent and adherent sublines of Walker carcinosarcoma cells: the role of cell-substratum contacts and microtubules in controlling cell shape, locomotion and cytoskeletal structure.

The international journal of biochemistry & cell biology·2002

Cell growth and division coordination is not solely dependent on cell growth rate. Extracellular signals regulate cell size variability in cultured rat Schwann cells.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Neuroscience

Background:

  • Sustained cell proliferation requires coordinated cell growth and cell division.
  • The prevailing hypothesis suggests cell growth rate limits cell-cycle progression, maintaining cell size.
  • Mechanisms coordinating cell growth and division remain incompletely understood.

Purpose of the Study:

  • To investigate the relationship between cell growth and cell-cycle progression in rat Schwann cells.
  • To challenge the view that cell growth rate is the sole determinant of cell-cycle progression.
  • To elucidate how extracellular signals influence cell size maintenance during proliferation.

Main Methods:

  • Utilized purified rat Schwann cells in culture.
  • Applied two specific extracellular signal proteins, including glial growth factor (GGF).

Related Experiment Videos

  • Assessed the impact of GGF on cell growth (mass increase) and cell-cycle progression.

    • Main Results:

    • Glial growth factor (GGF) stimulated cell-cycle progression independently of cell growth.
    • Cell growth rate alone was not the determinant of cell-cycle progression rate.
    • Schwann cell size at division was variable and dependent on extracellular signal protein concentrations.

    Conclusions:

    • The coordination of cell growth and division is more complex than previously thought.
    • Extracellular signals play a critical role in regulating cell cycle progression and cell size.
    • Cell size is not rigidly maintained and can vary based on environmental cues.