Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac function during vagus escape.

M Mohan, U C Rai

    Indian Journal of Physiology and Pharmacology
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Vagal stimulation has a negative inotropic effect on ventricles, yet stroke volume increases during vagus escape. The Frank-Starling mechanism compensates for reduced heart rate to maintain cardiac output.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Optimizing adult nutrition and mating duration to improve mass rearing of Chrysoperla zastrowi sillemi.

    Scientific reports·2026
    Same author

    Energy-aware load balancing in cloud environments using graph neural networks and grey wolf optimization.

    Scientific reports·2026
    Same author

    Ultrastructural Insights Into the Reproductive Anatomy and Eggs of Cotton Pink Bollworm, Pectinophora gossypiella Saunders (Lepidoptera: Gelechiidae).

    Microscopy research and technique·2026
    Same author

    Molecular and functional characterization of pheromone-binding proteins in Leucinodes orbonalis Guenée (Lepidoptera: Crambidae).

    International journal of biological macromolecules·2026
    Same author

    Protected areas influence fire regimes globally.

    Journal of environmental management·2026
    Same author

    High levels of Bt cry toxin resistant allele frequency in South Indian populations of cotton pink bollworm, Pectinophora gossypiella Saunders (Gelechiidae: Lepidoptera).

    Journal of invertebrate pathology·2025
    Same journal

    Dr. A.P.J. Abdul Kalam : A Humble Tribute.

    Indian journal of physiology and pharmacology·2024
    Same journal

    Assessment of EEG as a Diagnostic and Prognostic Indicator Tool in the Febrile Seizures.

    Indian journal of physiology and pharmacology·2024
    Same journal

    Ictal EEG Non-linear And High Order Spectral Analysis Methods In Electroconvulsive Therapy And Its Clinical Utility.

    Indian journal of physiology and pharmacology·2024
    Same journal

    Nitric Oxide Synthases Blockade; L-NAME and Estradiol Alter Renal Blood Flow Response to Angiotensin 1-7 in Ovariectomized Rats.

    Indian journal of physiology and pharmacology·2024
    Same journal

    Leptin, Adiponectin and its Molar Ratio as a Biomarker in the Diagnosis of Metabolic Syndrome.

    Indian journal of physiology and pharmacology·2024
    Same journal

    The Effect of Maternal Age, Parity and Heamoglobin Level on Neonatal Birth Weight - A Fru Based Prevalence Study.

    Indian journal of physiology and pharmacology·2024
    See all related articles

    Area of Science:

    • Cardiology
    • Physiology
    • Neuroscience

    Background:

    • Vagal nerve stimulation's direct effect on ventricular myocardium is debated.
    • Recent studies indicate a negative inotropic effect of vagal stimulation on ventricles.

    Purpose of the Study:

    • To further investigate the effects of vagal stimulation on cardiac hemodynamics.
    • To elucidate the compensatory mechanisms involved in maintaining cardiac output during vagal stimulation.

    Main Methods:

    • Hemodynamic assessment in 15 dogs under nembutal anesthesia.
    • Bilateral vagotomy and stimulation of the peripheral vagus nerve.
    • Monitoring of heart rate, arterial pressure, cardiac output, and stroke volume.

    Main Results:

    Related Experiment Videos

    • Bilateral vagotomy increased heart rate, arterial pressure, and cardiac output, while decreasing stroke volume.
    • Vagal stimulation caused cardiac standstill followed by vagus escape.
    • During vagus escape, arterial pressure, heart rate, and cardiac output decreased, but stroke volume significantly increased.

    Conclusions:

    • The Frank-Starling mechanism plays a significant role in maintaining cardiac output during vagal stimulation.
    • Increased stroke volume compensates for decreased heart rate, despite the negative inotropic effect of vagal stimulation.
    • These findings highlight the adaptive capacity of the cardiovascular system in response to vagal nerve activity.