A tour of structural genomics
Related Experiment Video
Updated: Feb 27, 2026

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
Published on: December 13, 2024
1Department of Plant and Microbial Biology, University of California, 461A Koshland Hall, Berkeley, California 94720-3102, USA. brenner@compbio.berkeley.edu
Abstract:
Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models are expected to yield insight into the molecular function and mechanism of thousands of proteins. The pervasiveness of this information is likely to change the use of structure in molecular biology and biochemistry.
Related Concept Videos
Modern Molecular Taxonomy
Genomics
Genome Annotation and Assembly
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Evolutionary Relationships through Genome Comparisons
Organization of Genes

