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A tour of structural genomics.

S E Brenner1

  • 1Department of Plant and Microbial Biology, University of California, 461A Koshland Hall, Berkeley, California 94720-3102, USA. brenner@compbio.berkeley.edu

Nature Reviews. Genetics
|October 5, 2001
PubMed
Summary

Structural genomics initiatives are determining 3D protein structures for all genome-encoded macromolecules. This large-scale effort will reveal molecular functions and mechanisms, transforming molecular biology and biochemistry.

Area of Science:

  • Structural biology
  • Genomics
  • Biochemistry

Background:

  • Structural genomics aims to map the 3D structures of all proteins encoded by genomes.
  • Understanding protein structure is crucial for elucidating molecular function and mechanisms.

Purpose of the Study:

  • To assess the feasibility of large-scale, high-throughput protein structure determination.
  • To generate a comprehensive structural database for genomic-encoded macromolecules.

Main Methods:

  • Utilizing experimental structure determination (e.g., X-ray crystallography, NMR spectroscopy).
  • Employing computational modeling techniques to predict protein structures.
  • Coordinating efforts across multiple pilot centers worldwide.

Main Results:

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  • Pilot centers are actively exploring and validating methods for large-scale structure determination.
  • Generation of numerous experimental and computational 3D protein models is underway.
  • The project is on track to provide structural insights for thousands of proteins.

Conclusions:

  • Large-scale structural genomics projects are feasible and progressing.
  • The resulting structural data will significantly advance the understanding of protein function and mechanisms.
  • This pervasive structural information is poised to revolutionize molecular biology and biochemistry.