Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

249
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
249
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.0K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

14.0K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.0K
Rh Blood Group01:19

Rh Blood Group

2.7K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.7K
Blood Transfusion01:15

Blood Transfusion

2.1K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.1K
Blood Typing01:10

Blood Typing

2.3K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function.

FASEB bioAdvances·2019
Same author

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Nature communications·2019
Same author

Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.

Oncogene·2014
Same author

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.

Endocrinology·2013
Same author

Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner.

Oncogene·2013
Same author

Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.

Endocrinology·2011
Same journal

Human aminoacyl-tRNA synthetases as integrators of translation and cell signalling networks.

Nature reviews. Molecular cell biology·2026
Same journal

How proteins fold.

Nature reviews. Molecular cell biology·2026
Same journal

Single-cell evidence for PANoptosome complexes.

Nature reviews. Molecular cell biology·2026
Same journal

Reply to 'Single-cell evidence for PANoptosome complexes'.

Nature reviews. Molecular cell biology·2026
Same journal

Plucking cellular ribosomes with Ribo-Tweezer.

Nature reviews. Molecular cell biology·2026
Same journal

COPII meets autophagy at the ER membrane.

Nature reviews. Molecular cell biology·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Disorders of Erythrocytes
01:27

Disorders of Erythrocytes

2.0K

PKB/AKT: functional insights from genetic models.

M P Scheid1, J R Woodgett

  • 1Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

Nature Reviews. Molecular Cell Biology
|October 5, 2001
PubMed
Summary
This summary is machine-generated.

Protein kinase B (PKB)/AKT functions are increasingly understood, but recent studies question established mechanisms. New research suggests other factors may be involved in PKB/AKT signaling pathways.

More Related Videos

Immune Compatible Blood Transfusion and Agglutination
02:45

Immune Compatible Blood Transfusion and Agglutination

14.0K
Rh Blood Group
01:19

Rh Blood Group

2.7K

Related Experiment Videos

Last Updated: Jan 10, 2026

Disorders of Erythrocytes
01:27

Disorders of Erythrocytes

2.0K
Immune Compatible Blood Transfusion and Agglutination
02:45

Immune Compatible Blood Transfusion and Agglutination

14.0K
Rh Blood Group
01:19

Rh Blood Group

2.7K

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Protein kinase B (PKB)/AKT is a crucial signaling molecule discovered a decade ago.
  • Its diverse cellular functions have been extensively studied and cataloged.
  • Recent findings challenge the established understanding of PKB/AKT's roles.

Purpose of the Study:

  • To critically evaluate the physiological relevance of proposed PKB/AKT signaling mechanisms.
  • To explore new insights into PKB/AKT function based on recent research.
  • To identify potential alternative or complementary players in PKB/AKT-mediated pathways.

Main Methods:

  • Review of recent scientific literature and experimental findings.
  • Application of novel reagents and advanced research approaches.
  • Comparative analysis of established versus emerging data on PKB/AKT.

Main Results:

  • Established mechanisms of PKB/AKT action are being re-evaluated.
  • New experimental data reveal limitations in the current understanding of PKB/AKT.
  • Evidence suggests that other signaling molecules may contribute to PKB/AKT effects.

Conclusions:

  • The precise physiological roles of PKB/AKT require further investigation.
  • Existing models of PKB/AKT signaling may be incomplete.
  • Future research should consider the involvement of additional cellular components in PKB/AKT pathways.