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Cortisol differentially affects memory in young and elderly men.

O T Wolf1, A Convit, P F McHugh

  • 1Center for Brain Health, New York University School of Medicine, New York 10016, USA.

Behavioral Neuroscience
|October 5, 2001
PubMed
Summary
This summary is machine-generated.

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Cortisol impaired memory recall before treatment in both young and elderly men. However, cortisol only reduced working memory in younger individuals, suggesting age-related differences in cognitive effects.

Area of Science:

  • Neuroscience
  • Psychology
  • Endocrinology

Background:

  • Stress hormones like cortisol can impact cognitive functions.
  • Age-related changes in the brain may alter responses to stress hormones.

Purpose of the Study:

  • To investigate the effects of cortisol on memory and working memory in young versus elderly men.
  • To explore potential age-dependent differences in cognitive responses to cortisol.

Main Methods:

  • A placebo-controlled, double-blind, crossover study involving 9 young and 11 elderly men.
  • Administration of cortisol (0.5 mg/kg) or placebo, with memory recall and cognitive tests (Digit Span, Stroop Test) administered.
  • Word list learning and delayed recall tested before and after drug administration.

Related Experiment Videos

Main Results:

  • Cortisol reduced delayed recall of a word list learned before treatment in both age groups.
  • Cortisol impaired Digit Span (working memory) performance in young men but not in elderly men.
  • Cortisol did not affect the recall of word lists learned after drug administration.

Conclusions:

  • Cortisol has differential effects on cognitive functions based on age.
  • Age-associated brain changes may influence the impact of cortisol on working memory.
  • Further research is needed to understand the neurobiological basis of these age-related differences.