Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Photodynamic therapy in oncology.

C H Sibata1, V C Colussi, N L Oleinick

  • 1Case Western Reserve University and University Hospitals of Cleveland, Department of Radiation Oncology, Ohio 44106, USA. cxs81@po.cwru.edu

Expert Opinion on Pharmacotherapy
|October 5, 2001
PubMed
Summary

Photodynamic therapy (PDT) uses photosensitizers and light to kill cancer cells. Newer agents offer improved light penetration and reduced side effects, expanding PDT

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical PD/PDT in North America: An historical review.

Photodiagnosis and photodynamic therapy·2014
Same author

PD/PDT for gynecological disease: A clinical review.

Photodiagnosis and photodynamic therapy·2014
Same author

PDT experience in Brazil: A regional profile.

Photodiagnosis and photodynamic therapy·2014
Same author

Clinical photodynamic therapy of head and neck cancers-A review of applications and outcomes.

Photodiagnosis and photodynamic therapy·2014
Same author

Consistency of vendor-specified activity values for ¹⁹²Ir brachytherapy sources.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2011
Same author

Successful cutaneous delivery of the photosensitizer silicon phthalocyanine 4 for photodynamic therapy.

Clinical and experimental dermatology·2011

Area of Science:

  • Oncology
  • Photochemistry
  • Biomedical Engineering

Background:

  • Photodynamic therapy (PDT) is a cancer treatment using photosensitizers and light.
  • First-generation photosensitizers like Photofrin have limitations in light penetration and cause skin sensitivity.
  • Newer photosensitizers offer improved tissue penetration and faster clearance from normal tissues.

Purpose of the Study:

  • To review the current applications of first- and second-generation photosensitizers in oncology.
  • To discuss the advantages and limitations of existing PDT treatments.
  • To highlight advancements in photosensitizer development and light delivery systems.

Main Methods:

  • Review of existing literature on photodynamic therapy in oncology.
  • Analysis of the properties and clinical applications of first- and second-generation photosensitizers.
  • Discussion of emerging technologies and future directions in PDT.

Main Results:

  • PDT is effective for specific cancer types but not yet a general cancer treatment.
  • Newer photosensitizers exhibit enhanced properties, including deeper light penetration and reduced normal tissue toxicity.
  • PDT can be safely repeated and used in conjunction with other cancer therapies.

Conclusions:

  • Advancements in photosensitizer technology and light delivery are addressing current PDT limitations.
  • Further research into PDT mechanisms and protocols promises improved treatment outcomes.
  • PDT holds potential as a versatile and repeatable cancer treatment modality.

Related Experiment Videos