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Diastolic dysfunction: insights into pathophysiology and pharmacotherapy.

C V Maniu1, M M Redfield

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

Expert Opinion on Pharmacotherapy
|October 5, 2001
PubMed
Summary

This review examines diastolic dysfunction, particularly isolated diastolic dysfunction where only diastolic function is impaired. It covers influencing factors, clinical aspects, therapeutic targets, and recent trials for managing this heart condition.

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Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Diastolic dysfunction is a significant clinical issue.
  • Isolated diastolic dysfunction occurs without reduced systolic function.

Purpose of the Study:

  • To review the pathophysiology of diastolic dysfunction.
  • To explore the clinical spectrum and therapeutic targets.
  • To summarize recent pharmacological trials and recommendations.

Main Methods:

  • Literature review of diastolic dysfunction.
  • Analysis of physiological mechanisms.
  • Evaluation of clinical trials and treatment strategies.

Main Results:

  • Diastolic dysfunction encompasses various phenomena affecting heart relaxation.

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  • Isolated diastolic dysfunction presents a distinct clinical profile.
  • Several physiological perturbations offer potential therapeutic targets.

    • Conclusions:

    • Understanding diastolic dysfunction is crucial for effective patient management.
    • Pharmacological therapies targeting specific perturbations show promise.
    • Current recommendations guide the therapeutic approach to diastolic dysfunction.