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Diastolic dysfunction: insights into pathophysiology and pharmacotherapy
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Insights
This review examines diastolic dysfunction, particularly isolated diastolic dysfunction where only diastolic function is impaired. It covers influencing factors, clinical aspects, therapeutic targets, and recent trials for managing this heart condition.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Diastolic dysfunction is a significant clinical issue.
- Isolated diastolic dysfunction occurs without reduced systolic function.
Purpose of the Study:
- To review the pathophysiology of diastolic dysfunction.
- To explore the clinical spectrum and therapeutic targets.
- To summarize recent pharmacological trials and recommendations.
Main Methods:
- Literature review of diastolic dysfunction.
- Analysis of physiological mechanisms.
- Evaluation of clinical trials and treatment strategies.
Main Results:
- Diastolic dysfunction encompasses various phenomena affecting heart relaxation.
- Isolated diastolic dysfunction presents a distinct clinical profile.
- Several physiological perturbations offer potential therapeutic targets.
Conclusions:
- Understanding diastolic dysfunction is crucial for effective patient management.
- Pharmacological therapies targeting specific perturbations show promise.
- Current recommendations guide the therapeutic approach to diastolic dysfunction.
Abstract:
This review focuses on diastolic dysfunction with special emphasis on isolated diastolic dysfunction where impairment in diastolic function occurs in the absence of concomitant reduction in systolic function. The phenomena which influence diastolic function, the clinical spectrum of diastolic dysfunction, the physiological perturbations which may serve as therapeutic targets for pharmacological therapy and recent therapeutic trials are reviewed. Recommendations regarding the therapeutic approach to the patient with diastolic dysfunction are summarised.