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Related Experiment Videos

Mifepristone: a potential postcoital contraceptive.

P C Ho1

  • 1Department of Obstetrics and Gynaecology, University of Hong Kong. pcho@hkusub.hku.hk

Expert Opinion on Pharmacotherapy
|October 5, 2001
PubMed
Summary

Mifepristone effectively acts as an emergency contraceptive and can regulate menstruation. Lower doses maintain efficacy while reducing menstrual delays, though its abortion pill reputation may limit access.

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Area of Science:

  • Reproductive Endocrinology
  • Pharmacology

Background:

  • Mifepristone is a progesterone receptor antagonist.
  • Its effects vary depending on the phase of the menstrual cycle.

Purpose of the Study:

  • To evaluate mifepristone's efficacy and side effects as a contraceptive and for menstrual regulation.
  • To assess the impact of different dosing regimens.

Main Methods:

  • Administration of mifepristone at different points in the menstrual cycle.
  • Clinical trials assessing contraceptive and menstrual regulation efficacy.
  • Comparison with other contraceptive methods and prostaglandin combinations.

Main Results:

  • Single-dose mifepristone in the early luteal phase shows contraceptive potential, limited by LH surge detection.
  • Mifepristone with prostaglandins aids menstrual regulation but has cost/side effect limitations.
  • Mifepristone is effective for emergency contraception with fewer side effects than the Yuzpe regimen.
  • Lower doses (10 mg) are effective and reduce menstrual delay.

Conclusions:

  • Mifepristone demonstrates significant utility in emergency contraception and menstrual regulation.
  • Dose reduction maintains efficacy while improving the menstrual cycle profile.
  • Wider clinical application may be hindered by its association with abortion and prostaglandin-related limitations.

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