Chromosome 12 and late-onset Alzheimer's disease

¹Division of Neurology, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430, USA. neusep@ttuhsc.edu

|October 5, 2001

Abstract:

Alzheimer's disease is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. Using large extended families with multiple affected, we found that three markers on chromosome 12 were linked with late-onset Alzheimer's disease. These markers were downstream from the gene for alpha-2 macroglobulin. It is likely that multiple genes will be identified either as risk factors or as causative agents for late-onset Alzheimer's disease.

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Abstract:

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